α-Galactosylceramide: a potent immunomodulator produced by gut microbes
نویسندگان
چکیده
منابع مشابه
Production of α-Galactosylceramide by a Prominent Member of the Human Gut Microbiota
While the human gut microbiota are suspected to produce diffusible small molecules that modulate host signaling pathways, few of these molecules have been identified. Species of Bacteroides and their relatives, which often comprise >50% of the gut community, are unusual among bacteria in that their membrane is rich in sphingolipids, a class of signaling molecules that play a key role in inducin...
متن کاملConagenin, a low molecular weight immunomodulator produced by Streptomyces roseosporus.
effect on T lymphocytes. Fermentations for the production of conagenin were done as follows. S. roseosporus was cultured in 500-ml Erlenmeyer flasks containing 1 10 ml of the autoclaved seed medium consisting of galactose 2.0%, dextrin 2.0%, soy peptone 1.0%, corn steep liquor 0.5%, (NH4)2SO4 0.2%, CaCO3 0.2% and one drop of silicone. The seed medium was adjusted to pH 7.4 with 1 n HC1 and was ...
متن کاملLipid metabolism by gut microbes and atherosclerosis.
A recent metabolomic study provides evidence that microbial metabolism of lipids in the gut yields product(s) that promote atherosclerosis. These results add another dimension—the microbiome—to the complex determinants of atherogenesis. Atherosclerotic vascular disease is a complex pathophenotype that is governed by genetic and environmental determinants. The mechanistic interplay between speci...
متن کاملUremic Solutes Produced by Colon Microbes.
BACKGROUND Colon microbes produce a large number of organic compounds that are foreign to mammalian cell metabolism. SUMMARY Some of the compounds made by microbes are absorbed in the colon and then normally excreted by the kidneys. Accumulation of these compounds in the plasma as uremic solutes may contribute to illness in patients whose kidneys have failed. Mass spectrometry is expanding ou...
متن کاملSelect: Gut Microbes
Our intestines host trillions of bacteria, most of which are beneficial to our health most of the time. Occasionally, however, a change in conditions, or the entry of a pathogenic strain, leads to disease. Recent papers shed new light onto the complex interactions that determine intestinal health and disease. Intestinal cells first come into contact with bacteria after birth, as they transition...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 2019
ISSN: 0022-2275
DOI: 10.1194/jlr.c119000437